Additionally, fibroblast growth factor (FGF), which is also secreted by adipose tissue-derived stromal cells [77,78] has been shown to induce E-cadherin down regulation via PI3K/Akt/mTOR and MAPK/ERK in OVCAR4 and SKOV3 human ovarian cancer cells [79]. Here, CDH1 is linked to ovarian carcinoma.