Finally, MCP-1, which is produced by adipocytes, has been shown to induce migration and omental metastasis by binding to its cognate receptor CCR-2 on ovarian cancer cells and in turn activating the PI3K/AKT/mTOR pathway and its downstream effector HIF-1a and VEGF-A [91,92]. The gene discussed is AKT1; the disease is ovarian carcinoma.