For example, induction of ISG15 or IFIT1 in human squamous cell carcinoma cancer cell line conferred doxorubicin chemo-resistance [49], or overexpression of IFIT1 and IFIT3 in oral squamous cell carcinoma (OSCC) promoted experimental metastasis [50]. The gene discussed is IFIT1; the disease is oral cavity squamous cell carcinoma.