This phenomenon has also been described for other “classical” and long-established tumor antigens, such as Her2neu, WT1, NY-ESO-1 and p53, for which only a limited or even absent HLA-bound presentation was observed, despite a tumor-associated overexpression at the mRNA level [4,5,6,7,8,9,10,11]. This evidence concerns the gene WT1 and neoplasm.