SMO and meningioma: Meningiomas with AKT1 p.Glu17Lys mutations tend to have a skull-base or basal localization [35,36], SMO-mutated meningiomas predominate in the medial anterior skull base [18,37], PIK3CA-mutant meningiomas are preferentially localized at the skull base [19], and POLR2A-mutated meningiomas are mainly found in the tuberculum sellae region [23].