Most intraventricular meningiomas (44%) harbor NF2 mutations in the series of Jungwirth et al., while in non-NF2-mutated intraventricular meningiomas, genetic alterations including TRAF7, AKT1, SMO, KLF4, PIK3CA, and TERT are lacking, thus suggesting a role for alternative genes in the pathogenesis of non-NF2 intraventricular meningiomas. The gene discussed is KLF4; the disease is intraventricular meningioma.