Previous tissue-based studies of intestinal MCs in human CRC either used no MC subtyping (histochemical stainings) [21,22] or IHC-based methodologies to subtype MCs regarding to their protease content as follows: tryptase (MCT) [3,5,9,23]; chymase (MCC); or tryptase and chymase (MCTC) positive (+) MCs [7,8,24,25]. Here, CMA1 is linked to colorectal carcinoma.