Doxycycline-inducible expression of oncogenic KRAS in brain cells under the control of the krt5 and gfap gene promoters using the TetOn system (Tg(TRE:mCherry-KRASG12V; krt5/gfap:rtTa)) led to the development of malignant tumors in the cranial cavity and parenchymal brain tumors, respectively [72]. The gene discussed is KRT5; the disease is brain neoplasm.