Furthermore, human or murine oncogene transgenic expression in zebrafish has also helped to understand their role in tumor development; for example, Tg(ptf1a:eGFP-KRASG12V) in pancreatic cancer [65] and Tg(mitfa:HRASG12V; mitfa:GFP) or Tg(mitfa:BRAFV600E); tp53−/− for melanoma [66,67]. This evidence concerns the gene MITF and melanoma.