MMP2 and neoplasm: The cytokine A Proliferation-Inducing Ligand (APRIL), produced by tumor cells, and B-cell Activating Factor (BAFF), IL-8, and Matrix Metallopeptidase 2 (MMP2), produced by a variety of tissue and blood cells, have been reported to be inversely correlated with immune cell infiltration and expression of CD163, a marker of M2 macrophages in CRC [180].