In MSS mCRC, it has been shown that cytotoxic PD-1 high infiltration without Th17 infiltration in tumors that express PD-L1 has a TME similar to MSI-H CRC and was associated with anti-PD1 benefit [92], as already reported in melanoma and digestive cancers [93]. The gene discussed is PDCD1; the disease is colorectal carcinoma.