Activating mutations in Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha (PIK3CA), occurring in 25% of CRC cases [25], are associated with CD8+ T cell infiltration and Programmed Death-Ligand 1 (PD-L1) expression [26]. Here, PIK3CA is linked to colorectal carcinoma.