Recently, the new mENSAT TNM classification combined with GRAS parameters (Grade defined by Weiss score below or above 6 or Ki-67 below or above 20%; R0 resection status; age below or above 50 years; tumor- or hormone-related symptoms) was shown to allow the best risk stratification in term of OS in stage III–IV ACC patients [9]. The gene discussed is MKI67; the disease is adrenal cortex carcinoma.