This is in line with previous observations in pulmonary carcinomas [43], hepatocellular carcinoma [30], and gastric carcinomas [32], which suggested a specific role for nucleolin at the cytoplasm and membrane subcellular localizations during lung carcinogenesis, yet to be determined, and as previously proposed for sirtuin 1 [47]. This evidence concerns the gene SIRT1 and hepatocellular carcinoma.