This was reinforced by Lai et al. upon the demonstration of lung tumor growth inhibition along with suppression of angiogenesis in a CL1-5 lung adenocarcinoma xenograft murine model (NOD-SCID) after tumor targeting with nucleolin aptamer-siRNA chimeras, which conveyed significant knockdown of snail family zinc finger 2 (SLUG) and neuropilin 1 (NRP1), key regulators of lung cancer cell metastasis and angiogenesis, respectively [63]. This evidence concerns the gene SNAI2 and lung cancer.