However, to the best of our knowledge, there are not studies which examined the relation between different ki67 threshold values and the predisposition to develop a breast cancer-related invasive disease event (IDE), which includes local recurrence, the appearance of distant visceral and soft tissue metastases, contralateral invasive breast cancer, or a second primary tumor [18], at different ages. Here, MKI67 is linked to invasive breast carcinoma.