The radiosensitivity of both NSCLC cell lines with mutant EGFR and human bronchial epithelial cells that stably express mutant forms of EGFR has been attributed to various aspects: (1) delayed DNA repair kinetics, (2) defects in the STOPs induced by radiation during DNA synthesis or in mitosis and (3) an increase in both the apoptotic phenomenon and the appearance of micronuclei. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.