Finer spatial analysis of the cancer–fibroblast interface and identification of the tip of invasive forks which directionally aligned parallel to the underlying nanofibers revealed that when MMP14 was silenced in stroma, the depth of invasive forks was markedly reduced suggesting that MMP14 contributed to fibroblast invasability, probably by assisting stromal matrix degradation (Figure 6F,G). The gene discussed is MMP14; the disease is cancer.