Gene expression analysis across all cancer samples for the ontologies showed high expression of genes encoding fibronectin (FN1) and collagen chains, particularly collagen-1A and collagen-3A, associated with fibrosis and connective tissue, as well as those for collagen 5A and SPARC which encodes a cysteine-rich acidic matrix-associated protein (Figure 3B and Figure S5). This evidence concerns the gene SPARC and cancer.