Interestingly, all the leading edge genes indicated a pro-oncogenic or pro-metastatic phenotype, including KLF5, Kruppel-like Factor 5 associated with poor survival in PDACs [71,72], NFKB1, nuclear factor kappa-light chain enhancer of activated B cells which is oncogenic and metastatic enhancers in PDAC cancers [73], heat shock protein binding 8 (HSPB8) which is oncogenic [74], MAP7D1 with unfavorable prognosis in liver and renal cancer [75], GMFB which encodes glia maturation factor beta associated with multiple types of cancers [76], as well as PSMD11, a biomarker for PDAC cancer [75]. The gene discussed is HSPB8; the disease is renal carcinoma.