In addition, we found another GO, collagen-associated ECM with high expression of RARRES2, encoding a tumor suppressor retinoic acid receptor responder also called chimerin [42] which phosphorylates β-catenin reducing fibrotic activity [43], CTHRC1 encoding a secreted Wnt modulator called collagen triple helix repeat containing 1, and a regulator of the healing scar process in myocardial infarction [44], and SERPINA1 encoding anti-trypsin peptidase antagonist. The gene discussed is CTHRC1; the disease is myocardial infarction.