Interestingly, stage IIB resulted in an increased expression of genes encoding constituents of collagen X (COL10A1), collagen X1 (COL11A1), and collagen XII (COL12A1) isoforms, which have been reported to be prognostic markers of pancreatic cancer metastasis [40,41] (Figure 3D and Figure S6). The gene discussed is COL12A1; the disease is familial pancreatic carcinoma.