CTSB and neoplasm: Cancer-induced platelet activation can occur via the generation of small amounts of thrombin by tumor cells- or tumor microvesicle-expressed tissue factor [68,69,70], the secretion of ADP [68,70] or cathepsin B [71] by tumor cells, tumor cell-induced generation of neutrophil extracellular traps (NETs) [72,73], tumor cell-induced release of ADP and thromboxane A2 by platelets [63,70], or via direct engagement of platelet receptors with signaling properties such as CLEC-2 [58] and cadherin 6 [60] by tumor cell ligands.