We have previously established murine BM transplantation leukemia models (MBMTLM) of AML1/ETO9a (a truncated isoform of the AML1/ETO fusion) and CALM/AF10 driven leukemias and shown that the mice acquire additional somatic mutations during the latency period [36,37]. The gene discussed is RUNX1T1; the disease is leukemia.