Of note, eight pathways were associated with cardiovascular functions/diseases including hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), arrhythmogenic right ventricular cardiomyopathy (ARVC), adrenergic signaling in cardiomyocytes, cardiac muscle contraction, fluid shear stress and atherosclerosis, apelin signaling pathway, and vascular smooth muscle contraction. Here, APLN is linked to atherosclerosis.