Interestingly, clonal immunoglobulin in Gaucher disease-associated myeloma patients and mouse models were reactive against lyso-glucosylceramide (due to the fact of a glucocerebrosidase/glucosylceramidase deficiency), which was found to be elevated in both patients and in the mouse models, indicating lyso-glucosylceramide’s involvement in Gaucher disease-associated myeloma origins [164]. Here, GBA1 is linked to plasma cell myeloma.