DPYD and colorectal cancer: Similarly, increased SPHK2 expression levels correlate with augmented dihydropyrimidine dehydrogenase (DPD) in human colorectal cancer (CRC), and the inhibition of SPHK2 by SLR080811 effectively inhibits DPD expression and reverses 5-fluorouracil (5-FU) resistance in colorectal tumors of villin-Sphk2 Tg mice while also decreasing nuclear S1P concentration in tissues [22].