SPHK1 and neoplasm: For instance, SPHK1 overexpression is significantly associated with higher risks of tumor progression or worse prognostic outcome in colon adenocarcinoma (COAD), kidney renal clear cell carcinoma (KIRC), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), mesothelioma (MESO), and uveal melanoma (UVM) as indicated by the red bold outlines on the heatmap (Figure 3C).