Comparing the expression of other lung cancer-associated genes in the HCC827 cell line with preserved adenocarcinomatous phenotype under 2D and 3D conditions by PCR arrays revealed an upregulated transcription of anterior gradient protein 2 homolog (AGR2), carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), signal transducer and activator of transcription 2 (STAT2), transforming growth factor beta 1 (TGF-β1), TOX high mobility group box family member 3 (TOX3) and vascular endothelial growth factor A (VEGFA). The gene discussed is TOX3; the disease is lung cancer.