CD4 and neoplasm: Although long-term αCD4 antibody treatment failed to completely deplete CD4+ T cells in mice (Figure S3), the marked reduction in CD4+ T cells in Tslptg KrasG12D mice erased any differences between tumor size and percentage of lung surface area with tumor in Tslptg KrasG12D compared with KrasG12D mice (Figure 4a–c).