Both univariate (HR, 0.130; 95% CI, 0.018–0.953; p = 0.045) and MVA including the clinical factors grade, age, size and lymph node metastasis (HR, 0.006; 95% CI, 0.000–0.546; p = 0.026) showed that PDSs inducing lower expression of the EMT marker FOSL1 was significantly correlated with a poor prognosis of the patients in this subgroup, which could further be supported in Kaplan-Meier analyses (Figure 5A,B). This evidence concerns the gene FOSL1 and metastatic malignant neoplasm in the lymph nodes.