To further substantiate if the induced inter-PDS variability in gene expression was due to the preservation of intrinsic factors in the PDSs linked to clinical characteristics of the original cancer, we evaluated the associations between changes in gene expression and clinico-pathological features such as grade, ERα-status, PR (progesterone receptor)-status and metastasis in lymph nodes (LN) (Table 1, Supplementary Table S4). Here, ESR1 is linked to cancer.