This may have significant relevance in T-ALL as RUNX1 targets are involved in many critical cellular processes, especially in hematopoietic cells, such as cell differentiation, ribosome biogenesis, cell cycle regulation, and p53 and transforming growth factor beta (TGF-β) signaling pathways [29,75,76]. The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.