Indeed, different studies reporting functional assays on key proteins regulating fusion and fission, including OPA-1 and DRP1, highlight that overall fission has a crucial role in the maintenance of tumor proliferative capacity, migration potential, generation of ROS together with increased genomic instability, a decrease of patient survival, and reduction of metastatic potential of the cells as demonstrated in cell lines, animal models, tumor tissues, and patients. This evidence concerns the gene OPA1 and neoplasm.