When compared with glioblastoma-37-on-a-chip, glioblastoma-28-on-a-chip was more susceptible to O6BG (a pseudosubstrate of MGMT) and MX (a base excision repair pathway inhibitor), including the combination of O6BG + MX and the combination of CIS + KU + O6BG + radiation. Here, MGMT is linked to glioblastoma.