CD68-positive macrophages were more abundant in NEC than in non-NEC components in 20 (60.6%) and 25 (75.8%) cases, and CD163-positive macrophages were more abundant in NEC than in non-NEC components in 22 (66.7%) and 17 (51.5%) cases examined, in the intra-tumoral areas and invasive margins, respectively. The gene discussed is CD68; the disease is neuroendocrine carcinoma.