Therefore, we intend to use Tumor-TIL maps to guide the development of more sophisticated methods for advanced data mining efforts to explore the relationship of TILs with ductal histology, nuclear size (grade), and mitotic activity/Ki-67 proliferation in different histologic and molecular types of breast cancer [20,42,86,87,88,89,90]. The gene discussed is MKI67; the disease is neoplasm.