Such pathways include complement proteins activation aiding in cancer eradication, natural killer (NK) cells, cytotoxic immune cells which recognize and eliminate immunogenic cancerous cells, neutrophil protease activation, anti-tumor macrophages which display a pro-inflammatory like polarization playing a role in the elimination of immunogenic cancerous cells, CD4+ T-cells activation, the production of IL-22 promoting T-cells proliferation, and naïve B cells activation [14,15]. This evidence concerns the gene CD4 and neoplasm.