-LRP5/6 signaling plays a role in suppressing colitis-associated tumor-Deficiency of LRP5/6 resulted in a marked increase in p38 MAPK activation, which is critical for the expression of inflammatory factors-LRP5/6 deficient mice displayed a higher level of CD4+ cells producing IL-17A compared to wild type mice-Deletion of LRP5/6 in CD11c+ APCs resulted in lower levels of IL-22 production. The gene discussed is IL22; the disease is colitis.