-Intestinal secretory immunoglobulin A (sIgA) expression was decreased in the mice receiving fecal samples from colorectal cancer patients-Real-time PCR results showed an upregulation in the expression of pro-inflammatory cytokines such as NLRP3, TNF-α, and IL-1β.-Gut microbiota from colorectal cancer patients enhanced the activation of Wnt signaling pathway. This evidence concerns the gene IL1B and colorectal cancer.