-YYFZBJS reduced tumor multiplicity and numbers in the CRC mouse model-YYFZBJS treatment changed the composition of bacterial taxa in the colon-YYFZBJS induced multiple inflammatory pathways such as Treg/Th17 signaling leading to a significant expression of IL-6, IL-10, IL-17-YYFZBJS inhibited cellular proliferation through Enterotoxigenic Bacteroides fragilis primed T-regulatory cells. This evidence concerns the gene IL6 and colorectal carcinoma.