-Treatment with fucoidan increased cellular apoptosis and decreased tumor incidence and mean weight-Treatment with fucoidan decreased the expression of β-catenin C-Myc and CyclinD1-The level of NK cells, interferon-γ, IL-4, IL-10, and CD4 T cells were increased in the fucoidan treated models, while the levels of interleukin (IL)-17 and IL-23 were decreased. This evidence concerns the gene IL4 and neoplasm.