Since Fc-gamma receptors are key elements involved in ADCC, their polymorphisms were hypothesized to be associated with the magnitude of benefit from trastuzumab and the modification of anti-HER2 monoclonal antibodies’ Fc region has been proposed as a strategy to improve monoclonal antibodies-induced ADCC in patients with HER2-positive breast cancer [20]. Here, ERBB2 is linked to breast carcinoma.