Multivariable analysis is performed with consideration of the MIB-1 index (<20/≥20%), MGMT promoter status (hypermethylated/non-hypermethylated), preoperative intake of dexamethasone (yes/no), preoperative tumor area (≤967.4/>967.4), age (<65/≥65), and preoperative intake of antiepileptic drugs (yes/no). The gene discussed is MGMT; the disease is neoplasm.