The transgenic mice with Fbxo4−/− or Fbxo4−/+ genotypes can spontaneously develop various pathological conditions, including lymphoblastic lymphoma, extramedullary hematopoiesis/intense myeloid proliferation, hemangioma/angioinvasive tumor, dendritic cell tumor, histiocytic sarcoma, early myeloid tumor, mammary carcinoma, and uterine tumor [109]. Here, FBXO4 is linked to breast carcinoma.