Cyclin D1 is highly expressed in many human cancers including pancreatic adenocarcinoma, lung cancer, breast cancer, head and neck squamous cell carcinoma (HNSCC), cutaneous melanoma, endometrial cancer, colorectal carcinoma, ESCC, mantle cell lymphoma, and so forth [52,53,54,55,56,57,58,59,60,61,62,63,64,65,66]. The gene discussed is CCND1; the disease is head and neck squamous cell carcinoma.