The co-amplification of FXR1, protein kinase C, iota (PRKCI), and epithelial cell transforming 2 (ECT2) is detected in lung squamous cell carcinoma (LSCC) tissues; biologically, Fxr1 forms a complex with PRKCI and ECT2 to promote cell proliferation and invasion [93]. Here, FXR1 is linked to squamous cell lung carcinoma.