For example, reduced Fbxo4 expression is correlated with poor prognosis in patients with skin cutaneous melanoma (SKCM), rectum adenocarcinoma (READ), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), and sarcoma (SARC), but low Fbxo4 expression is associated with good prognosis in patients with brain lower grade glioma (LGG) and uveal melanoma (UVM) (Figure 6A–G). Here, FBXO4 is linked to rectum adenocarcinoma.