In addition, Fbxo4 also regulates the metastasis of breast cancer cells through controlling the stability of ICAM-1, which regulates the expression of epithelial–mesenchymal transition (EMT) markers, including E-cadherin (CDH1), Vimentin (VIM), Zinc finger E-box-binding homeobox 1 (ZEB1), and Snail Family Transcriptional Repressor 2 (SNAI2/SLUG) [25]. Here, ICAM1 is linked to breast cancer.