TNF and melanoma: BRAF-mutated melanomas were shown as immunologically cold tumors with a downregulated expression of major histocompatibility complex (MHC) class I molecules, low effector T-cell infiltration, and high regulatory T-cells (Tregs), high myeloid-derived suppressor cells (MDSCs) infiltrates, as well as the accumulation of immunosuppressive interleukins (IL-6, IL-10) in the tumor niche, as well as impaired maturation of dendritic cells (DC) and their capacity to secrete proinflammatory cytokines (IL-12 and TNFα) [15,16,17].