Moreover, patients with BRAF V600E/K–mutant melanoma who received a previous BRAFi with or without MEKi had lower objective response rates (28.4% vs. 44.2%), four-year PFS (15.2% vs. 27.8%), and OS (26.9% vs. 49.3%), compared with those who had not received earlier targeted therapy [35]. The gene discussed is BRAF; the disease is melanoma.