Our group reported a previous systematic review on conventional NPC prognostic factors [10], including the EBV-DNA level, primary gross tumor volume (GTV), nodal GTV, neutrophil–lymphocyte ratio (NLR), C-reactive protein (CRP)/albumin ratio, anemia, platelet count, lactate dehydrogenase (LDH), and maximum standardized uptake value (SUVmax) of the primary tumor and total lesion glycolysis (TLG). This evidence concerns the gene CRP and anemia (phenotype).