Our group reported a previous systematic review on conventional NPC prognostic factors [10], including the EBV-DNA level, primary gross tumor volume (GTV), nodal GTV, neutrophil–lymphocyte ratio (NLR), C-reactive protein (CRP)/albumin ratio, anemia, platelet count, lactate dehydrogenase (LDH), and maximum standardized uptake value (SUVmax) of the primary tumor and total lesion glycolysis (TLG). The gene discussed is CRP; the disease is nasopharyngeal carcinoma.