In line with these distinct alterations of epigenetic modifiers, we identified transcriptional downregulation of essential cell cycle components and EZH2 targets (Figure 3C), such as CDK2, and upregulation of well-known cell cycle inhibitors and tumor suppressors, such as CDKN1A and PDCD4 (Programmed Cell Death 4), whose expression has been associated with epigenetic regulation [43]. This evidence concerns the gene CDKN1A and neoplasm.