RHOA and pachyonychia congenita: Regarding the detailed mechanism, researchers found that GEM could increase the expression of drosha ribonuclease III (drosha) and DGCR8 microprocessor complex subunit (DGCR8) to promote the generation of the miR-1207 pair from the PVT1 transcript, thereby disrupting oncogenic signaling in PC cells by targeting ras homolog family member A (RhoA) and the SRC proto-oncogene (nonreceptor tyrosine kinase) [234].