To identify the most representative genes of the signature related to Stage AJCC, we performed a forward search feature selection Variable Ranking Based on Mutual Information Difference, resulting in a 13-gene signature (AR, AL353637.1, DPP6, FOXJ1, GNB3, HHLA2, IL4, LIMCH1, LINC01732, OTX1, SAA1, SEMA3G, ZIC2–Figure A3) able to predict distinct outcomes (high, moderate, and low survival risk) of patients with ccRCC. The gene discussed is HHLA2; the disease is nonpapillary renal cell carcinoma.