SEMA3G belongs to the family of class-3 semaphorins, and studies indicate that this gene is linked to kidney diseases [80,81], suggesting important roles with neuropilin and plexin families in the etiology of cancer [82], and it is also an inhibitor of glioma progression by competing with VEGF for receptor NRP1 [83]. The gene discussed is NRP1; the disease is central nervous system cancer.