From our 13-gene signature, a subset of eight genes had been reported previously in distinct signatures for ccRCC, including other recent signatures that were not compared in our benchmark: AR [19,51], SEMA3G [19,52,53], LIMCH1 [9], DPP6 [54,55], FOXJ1 [56,57], ZIC2 [11], IL4 [19,58,59,60], and OTX1 [12]. This evidence concerns the gene ZIC2 and nonpapillary renal cell carcinoma.