PLAUR and melanoma: The interaction of uPAR to integrins, induces the mitogenic Raf-MEK-ERK signaling pathways, which are important for melanoma dormancy as well as tumor cell migration, thus suggesting a possible correlation between these two events [45] In fact, the inhibition of uPAR, integrin β1 or EGFR, either alone or combined, prompts dormancy and tumor suppression [79].