Enhancement of the T-cell antitumor response is mediated by blocking the Lymphocyte activation gene-3 (LAG-3), glucocorticoid-induced TNF receptor (GITR) and T cell immunoreceptor with immunoglobulin and ITIM domain (TIGIT), with subsequent T-cell effectors and NK cell proliferation, release of pro-inflammatory cytokine, and inhibition of Treg cells resulting in a more effective eradication of dormant cancer cells [97]. The gene discussed is LAG3; the disease is cancer.