Subsequently, TGF-β expression correlates with dedifferentiated melanoma cells, and in association with the increased expression of ZEB2/SLUG/MITF, may mediate phenotype-switching from melanocyte-like and hyperdifferentiated/pigmented state to SMC, intermediate melanoma cells, NCS to undifferentiated cells [55,56]. The gene discussed is TGFB1; the disease is melanoma.