Data on melanoma have been confirmed in genetically engineered mice with the development of invasive melanoma after the inactivation of LKB1 in a K-Ras-driven melanoma model and by evidence of endothelial transdifferentiation in BRAFV600E-metastatic biopsies from the human lung, brain, and small intestine [40,41]. This evidence concerns the gene KRAS and melanoma.