Other relevant factors in dormancy escape are the increased levels of interferon gamma IFN-γ and re-expression of glucocorticoid-induced leucine zipper (GILZ).IFN-γ modulates CD4+-Tcell viability and the expression of immune-checkpoint molecules and changes in tumor-associated macrophage polarization with the subsequent stimulation of cell proliferation and angiogenesis, and the development of macrometastasis [90,91]. Here, CD4 is linked to neoplasm.