For this stage, there are several markers for melanoma-initiation, such as MAGE proteins, GalNAc-T, NG2, CSPG4, ABCB5, MAGEA3, PAX3, TGFB2, TYR2, Human Melanoma Black-45 (HMB-45), Melan-A, tyrosinase, and S100 [7,8,9,10,11,12,13,14,15,16,17,18]. The gene discussed is PMEL; the disease is melanoma.