Many targets have been identified for CAR-T-cell therapy for BC such as mesothelin, epidermal growth factor receptor (EGFR), intercellular adhesion molecule-1 (ICAM), Mucin1 glycoprotein (MUC1), receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) and tumor endothelial marker (TEM8). The gene discussed is ROR1; the disease is breast cancer.