PDCD1 and neoplasm: In a multicohort phase I/II trial (NCT03499899), ieramilimab (LAG525, a monoclonal antibody blocking binding of LAG-3 to MHC-II) plus spartalizumab (a monoclonal antibody blocking the interaction of PD-1 with PD-L1 and PD-L2) produced durable responses in women with mTNBC associated with a switch from an immune-cold to an immune-activated biomarker profile in tumor biopsies [127].