CD274 and neoplasm: The study had four prespecified coprimary endpoints using PD-L1 as the stratification parameter: (1) PFS tested in parallel in both the ITT population and (2) in patients with PD-L1-expressing ICs covering ≥1% of the tumor area (IC-positive), (3) OS-tested hierarchically in the ITT population and then, if significant, (4) in the PD-L1 IC-positive population.