ERBB2 and breast cancer: In the phase II SAFIR02-BREAST IMMUNO trial (NCT02299999), 199 patients with HER2-negative metastatic BC, who did not progress after six to eight cycles of induction CT and lacking a targetable molecular alteration, were randomized 2:1 to durvalumab or CT (paclitaxel, capecitabine and fluorouracil/epirubicin/cyclophosphamide) as the maintenance therapy.