In multivariate analysis with the Cox proportional hazards model, elevated alpha-fetoprotein (AFP; ≥100 ng/mL; hazard ratio [HR] 2.190, p < 0.001), multiple tumors (HR 1.784, p = 0.006), tumor size of ≥5 cm (HR 1.508, p = 0.032), and neo-GPS of ≥1 (HR 1.554, p = 0.019) were significant prognostic factors for OS, whereas elevated AFP (≥100 ng/mL) (HR 1.743, p < 0.001), multiple tumors (HR 1.537, p = 0.004), and neo-GPS of ≥1 (HR 1.522, p = 0.001) were significant prognostic factors for PFS. This evidence concerns the gene AFP and neoplasm.