Clinically, serum and plasma samples from patients with B-ALL exhibit increased levels of pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10, interleukin-12, interferon-γ (IFN-γ) and CCL2 [133,134]. Here, TNF is linked to precursor B-cell acute lymphoblastic leukemia.