Pharmacological inhibition of osteoclastic bone resorption with zoledronic acid [91], a bisphosphonate used for the treatment of osteoporosis, or with recombinant osteoprotegerin-Fc [100], an antagonist of RANKL, successfully prevented B-ALL-mediated bone loss in mouse models of B-ALL. This evidence concerns the gene TNFSF11 and precursor B-cell acute lymphoblastic leukemia.