One of the abscopal effect mechanisms is the radiation-induced danger signals, in which calreticulin (CRT) is translocated to the cell surface and high mobility group box-1 (HMGB-1) are released from dying cells, thereby facilitating dendritic cells to recognize tumor antigens, followed by T cell activation and clonal expansion [13,14,15]. The gene discussed is HMGB1; the disease is neoplasm.