Vanpouille-Box et al. demonstrated that the accumulation of dsDNA, the expression level of proteins related to the cGAS-STING pathway, and the release of IFN-β were induced by high dose hypofractionated irradiation but not by a high radiation dose in a single fraction in murine breast cancer and colorectal carcinoma models [17]. The gene discussed is CGAS; the disease is breast cancer.