Previous studies demonstrated that tumor cell irradiation induces CRT translocation to the cell surface and the release of HMGB-1 in vitro, in vivo, and in humans [12,13,14,15,16,19,33], which promotes phagocytosis of dying tumor cells by dendritic cells through toll-like receptor 4 and mediates the cross-presentation of tumor antigens to CD8 T cells [13,14,15]. Here, HMGB1 is linked to neoplasm.