VANGL2 and colorectal carcinoma: Considering that the expression of common WNT-negative regulators (e.g., SDHA, PRKCD, PRKCA) was lost in CRLM, while at the same time activators (e.g., FERMT1, VANGL2, SRC) were highly upregulated, this implies that WNT signaling is hyperactive not only in primary CRC but also in CRLM.