IL5 and acute myeloid leukemia: Moreover, ILC3-derived IL-2 was essential in maintaining homeostasis of intestinal Tregs [63], Recently, Wu et al. revealed that mesenchymal stromal cells from patients with acute myeloid leukemia (AML) induced IL-5 secretion by ILC2s through prostaglandin D2 (PGD2)-CRTH2 axis in vitro [137].