In concordance with this observation, by measuring HLA-A, -B, and -C (HLA-ABC) expression in different tumor bulk cell populations ranging from triple-negative (OSN-) to triple-positive (OSN+), we observed a gradual downregulation of HLA-ABC genes towards the emergence of the c-GSC (OSN+) phenotype (Figure 1D). Here, HLA-A is linked to neoplasm.