To understand the link between ESC features and immune evasion in GSCs, we reprogrammed GBM-DCs into induced c-GSCs (ic-GSCs) by the ectopic expression of the four pluripotency-related transcription factors OCT4, KLF4, c-MYC, and SOX2 (Yamanaka factors [15]; Figure 2A). The gene discussed is SOX2; the disease is glioblastoma.