ZEB1 and familial pancreatic carcinoma: GRHL2 has been shown to regulate epithelial plasticity in pancreatic cancer [61], in sarcomas, where it forms with miR-200 and ZEB1 a gene regulatory network that may push sarcoma cells into an E-like state [62], and in basal-like and claudin-low breast cancer subtypes, in which re-expression of GRHL2 induced N- to ECAD switching consistent with the induction of MET [63].