H19 and familial pancreatic carcinoma: Recent studies have shown that H19 enhances invasion and metastasis in several malignancies, including bladder cancer [32,33], glioma [34], osteosarcoma [35], acute myeloid leukemia [36], breast cancer [37,38], non-small cell lung cancer [39], gastric cancer [40], and pancreatic cancer [41] while suppressing the aggressiveness of hepatocellular carcinoma [42] and prostate cancer [43].