Interestingly, GM3 is also able to induce MMP-2-mediated invasion of melanoma, and positively correlates with Ki-67 status in breast cancer, which is puzzling when considering that GM3 synthase silencing has been shown to decrease breast cancer metastases in vivo via NFAT1 inhibition [265,266,267,268,269]. This evidence concerns the gene ST3GAL5 and breast carcinoma.