We revealed that the expression of ICMs follows a high dynamic which is strongly time-dependent: in MCF-7 breast cancer cells, not earlier than 72 h after treatment and most pronouncedly after 120 h, three immunosuppressive ICMs, namely PD-L1, PD-L2 and HVEM, were upregulated in their expression following combined RT plus HT treatments, independently of the temperature. The gene discussed is PDCD1LG2; the disease is breast cancer.