LINC00844 and hepatocellular carcinoma: Importantly, bisulfite sequencing studies confirmed increased methylation levels of most CpGs analyzed within the promoter region of the five lncRNAs already identified to be hypermethylated in the TCGA cohort and similarly revealed higher methylation levels in the promoter CpGs of RP11-830F9.5, LINC00855 and LINC00844 in HCC samples compared to paired non-tumoral tissues (n = 7; Figure 2C).