The validity of our system of differential gene expression selection and the relevance of the selected Top35 LNDH is supported by the fact that some of them have been identified as deregulated in HCC by others, in high-throughput [21,37,38] or individual studies (LINC01093 [39,40], FAM99A [41], FAM99B [42], HAND2-AS1 [43,44], LINC00844 [45,46] or GBA3 [47]) being described as cell proliferation inhibitors, prognostic indicators, or potential biomarkers in HCC. This evidence concerns the gene HAND2 and hepatocellular carcinoma.