The reasons for high growth are: familial tall stature, constitutional advance of growth, aromatase deficiency, estrogen receptor α deficiency, congenital adrenal hyperplasia, growth hormone excess or hyperthyroidism, McCune–Albright syndrome, Beckwith-Wiedemann syndrome, Klinefelter syndrome, Triple X, fragile X, homocystinuria, Sotos and Weaver syndrome [48]. The gene discussed is ESR1; the disease is Klinefelter syndrome.