Among them, inflammation- or apoptosis-related Tlr2, Irf8, Ifih1 and Cxcl10 were listed in the top 60 genes of all topological features (DC, BC, CC, DC and EC); Stat3, Ccl2 and Casp1 were listed in the top 60 genes based on BC, CC, DC and EC ranking; Syk was considered as a hub gene according to CC, DC and EC ranking; Socs3 was believed as a hub gene according to BC and CC ranking. This evidence concerns the gene IRF8 and breast cancer.