In summary, our findings suggest that Socs3, Irf8, Crhbp and Gdf6 as well as the upstream mRNAs (Stat3, Tlr2-Syk), lncRNAs (9330175E14Rik, 6430562O15Rik, 4933406C10Rik and Gm9866) and miRNAs (miR-762, miR-207, miR-9 and miR-669b) that regulate these genes may be potential monitoring biomarkers and therapeutic targets associated with retinal injuries induced by NPs. Here, IRF8 is linked to retinitis.