Given that individuals with T1DM are recommended to participate in daily moderate-to-vigorous-intensity physical activity [31], and general guidance for glucose targets as well as nutritional and insulin dose adjustments to protect against exercise-related glucose excursions are available [9,20,21,26,27], fear of activity-related hypoglycemia has been regularly cited as a barrier to physical activity [32,33]. This evidence concerns the gene INS and type 1 diabetes mellitus.