Currently, PCOS has been considered a state of chronic and low-grade inflammation combined with increased production of specific cytokines and chemokines such as tumor necrosis factor (TNF)α, interleukin (IL)-1, IL-6, adhesion molecules implicated in endothelial dysfunction, follistatin, and c-reactive protein (CRP) [1]. The gene discussed is TNF; the disease is endothelial dysfunction.